Aim 1- Determine how PAR-1 mediates uPA/uPAR-driven PDAC tumor progression that exacerbates thrombosis in vivo.Aim 2 – Define the cell specific mechanisms of tumor cell- and CAF-derived PAR-1 and uPA/uPAR function in mediating tumor cell proliferation/invasion.
The UNC School of Medicine and Department of Pathology and Laboratory Medicine are housed within this structure. The three coequal missions of the UNC Department of Pathology and Laboratory Medicine are to: 1) provide exceptional, comprehensive pathology and laboratory medicine clinical services; 2) teach clinical and scientific concepts of pathology and laboratory medicine, and mechanisms of disease to a wide variety of learners; and 3) advance the practice of pathology and laboratory medicine, and the knowledge of diseases and disease mechanisms through innovative research spanning the spectrum from basic to translational to clinical. Departmental expertise in evaluating diseases and mechanisms of disease is in ever increasing demand by clinical and basic science faculty in other departments and centers, and collaborative contributions to multidisciplinary research at UNC is considered to be an important component of the overall research mission. Individual projects span the breath of biomedical sciences from mechanistic studies of essential cellular processes, using model systems in vitro as well as animal models, to clinical intervention studies in human populations. Specific research areas include mutagenesis and carcinogenesis, thrombosis and hemostasis, cardiovascular pathobiology, pathophysiology of renal glomerular diseases, renal transplant pathophysiology, molecular genetics, tissue differentiation and regeneration, animal models of human disease, discovery of new drugs against infectious agents, and development of new diagnostic methods.
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